Pharmacological Screening of Aquoues and Methanolic Extract of Moringa Oleifera for Anti-Inflammatory and Analgesic Activity

Abstract

Using a battery of experimental models, this
research compares the anti-inflammatory and
analgesic effects of Moringa oleifera leaf extracts.
Results from the tail flick test in rats and the acetic
acid-induced writhing in mice were used to
determine the analgesic efficacy of Moringa
oleifera leaves. Rats were tested for their ability to
reduce inflammation by inducing paw edoema with
carrageenan and by observing the growth of cotton
pellet-granulomas in rats. Also assessed were the
results of administering diclofenac, a reference
standard. The edoema caused by carrageenan in
rats' paws was significantly reduced after treatment
with the methanol extract. It was discovered that
the latency duration could be increased in the tail
flick approach more effectively using methanolic
and aqueous extracts. The findings corroborate the
traditional therapeutic usage of Moringa oleifera,
suggesting that it contains analgesic and antiinflammatory properties.