INTRANASAL TOPIRAMATE POLYMERIC NANOPARTICLES FOR EPILEPSY: IN VITRO AND EX- VIVO INVESTIGATION

Abstract

Tight connections in the blood-

highly difficult and drastically reduce the amount of therapeutic concentration that can reach the brain. The oral method of administration is the most convenient for treating epilepsy, however it does have a delayed absorption. Furthermore, due to the need for medical intervention, parenteral administration is not an option in emergency situations. For this reason, it is ideal to have a different way of administering the medication if we want it to work.